New Compound Could Better Protect from UVA Rays

Posted in Skin Care | August 15, 2016

skin careSun damage is the leading factor in skin aging. And around 95% of the ultraviolet radiation that reaches the Earth’s surface is ultraviolet A radiation. New research out of an English university has found a new compound that can provide a better shield in sunscreen against UVA rays.

At Deschutes, all of our patients battle with protecting their skin against the high altitude sun in the Bend area. So, we’re interested in this new finding and thought we’d pass on the info to our patients.

What is UVA radiation?

Most people know the types of radiation from what they see on sunscreen tubes. Most sunscreens are now called full spectrum, meaning they block both UVA and UVB rays. But it’s generally considered that they don’t do anywhere near as good a job on UVA rays as they do on UVB.

Why is this? For a long time, sunscreens were only concerned with UVB rays because those are the rays that cause sunburn on the epidermis, the top layer of the skin. All the while, scientists didn’t know that UVA rays were actually doing more damage. UVA rays penetrate the skin’s second layer, the dermis, damaging the collagen fibers. This leads to wrinkles and sun spots, but it also damages the DNA, which can trigger mutations that lead to skin cancer. UVA rays make up 95% of the sun’s rays that hit the Earth.

Another effect of UVA radiation

This study by the Department of Pharmacology at the University of Bath in the United Kingdom targeted another effect of UVA radiation. They found that UVA rays stimulate excess free iron present in cell mitochondria (the structures that produce energy in the cells). The stimulation of this free iron seems to fuel a reaction that causes damage to cell components, including DNA and various proteins. This damage then can lead to cell death, skin aging, and skin cancer. The study says that the role this free iron plays in damage to skin cells exposed to UVA rays has been underestimated for years.

A new compound

The researchers, whose findings were published in the Journal of Investigative Dermatogy, then developed a compound that prevented the free iron in mitochondria from reacting once it was exposed to UVA radiation. They called this compound the “mitoiron claw.” The mitoiron claw travels to mitochondria within cells, where it binds to the excess free iron.

To test the effect of their new compound, the researchers applied the mitoiron claw to human skin cells and exposed them to 140 minutes of continuous sea-level UVA radiation. Compared with untreated skin cells, the treated cells were highly protected against the UVA radiation.

Bottom line? A new additive to sunscreens

The next step would be to do further testing and then to add the mitoiron claw compound to sunscreens. Researchers think this could happen in the next 3-4 years. For your skin, that level of protection against UVA radiation damage could make a big difference in the way skin ages from sun exposure.

Of course, since such protection is still years away, your skin has to deal with the Central Oregon sun every day. Protect it, and then call Deschutes to schedule your yearly skin checkup. Call us at 541-330-0900 to make your appointment.


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